Etelcalcetide hydrochloride
Cat. No.：YN321988
| 产品名称: | Etelcalcetide hydrochloride |
| CAS No.: | 1334237-71-6 |
| Chemical Name: | N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide, disulfide with L-cysteine, hydrochloride |
| Synonyms: | AMG 416 hydrochloride; KAI-4169 hydrochloride |
| 分子量: | 1353.33 |
| 分子式: | C₃₈H₇₃N₂₁O₁₀S₂.₁₇/₂HCl |
| SMILES: | C[C@@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CSSC[C@H](N)C(O)=O)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Etelcalcetide hydrochloride (AMG 416 hydrochloride) 是一种合成肽，有钙敏感受体 (CaSR) 活化剂的作用。Etelcalcetide hydrochloride 可有效降低接受血液透析的继发性甲状旁腺功能亢进患者的甲状旁腺激素 (PTH) 浓度。 |
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Harada, K., Fujioka, A., Konno, M., et al.Pharmacology of Parsabiv® (etelcalcetide, ONO-5163/AMG 416), a novel allosteric modulator of the calcium-sensing receptor, for secondary hyperparathyroidism in hemodialysis patientsEur. J. Pharmacol.842,139-145(2019)
