CDN1163
Cat. No.：YN360091
CAS No. ：892711-75-0
| 产品名称: | CDN1163 |
| CAS No.: | 892711-75-0 |
| Chemical Name: | 4-(1-methylethoxy)-N-(2-methyl-8-quinolinyl)-benzamide |
| Synonyms: | CDN 1163;CDN-1163 |
| 分子量: | 320.39 |
| 分子式: | C₂₀H₂₀N₂O₂ |
| SMILES: | O=C(NC1=C2N=C(C)C=CC2=CC=C1)C3=CC=C(OC(C)C)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CDN1163 是一种肌膜/内质网Ca2+-ATPase (SERCA)的变构激活剂，可改善 Ca2+稳态。CDN1163 可减轻糖尿病和代谢紊乱。 |
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Kang, S., Dahl, R., Hsieh, W., et al.Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disordersJ. Biol. Chem.291(10),5185-5198(2016)
Qaisar, R., Bhaskaran, S., Ranjit, R., et al.Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weaknessRedox Biol.20,68-74(2019)
Dahl, R.A new target for Parkinson's disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned ratsBioorg. Med. Chem.25(1),53-57(2017)
