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Bepridil hydrochloride

Cat. No.:YN360130

  • CAS No. :68099-86-5

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    • 产品名称: Bepridil hydrochloride
      CAS No.: 68099-86-5
      Chemical Name: β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine, monohydrochloride
      Synonyms:CERM 1978
      分子量:403.00
      分子式:C₂₄H₃₅ClN₂O
      SMILES:[H]Cl.CC(C)COCC(N1CCCC1)CN(C2=CC=CC=C2)CC3=CC=CC=C3
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Bepridil hydrochloride (CERM 1978) 是一种钙离子通道 (calcium channel) 抑制剂,具有抗心绞痛的作用。
      IC50和靶点:
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    • Singh, B.N.The mechanism of action of calcium antagonists relative to their clinical applicationsBr. J. Clin. Pharmacol.21(Suppl 2),109S-121S(1986)

      Perez-Reyes, E., Van Deusen, A.L., and Vitko, I.Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: Block by antihypertensives, antiarrhythmics, and their analogsJ. Pharmacol. Exp. Ther.328(2),621-627(2009)

      Iijima, K., Chinushi, M., Izumi, D., et al.Effect of bepridil in atrial fibrillation inducibility facilitated by vagal nerve stimulation. Prevention of vagal nerve activation-induced shortening of the atrial action potential durationCirc. J.74(5),895-902(2010)

      Sinha, N., and Sen, S.Predicting hERG activities of compounds from their 3D structures: Development and evaluation of a global descriptors based QSAR modelEur. J. Med. Chem.46(2),618-630(2011)

      Sogaard, R., Ljungstrom, T., Pedersen, K.A., et al.KCNQ4 channels expressed in mammalian cells: Functional characteristics and pharmacologyAm. J. Physiol. Cell Physiol.280(4),C859-C866(2001)

      Li, Y., Sato, T., and Arita, M.Bepridil blunts the shortening of action potential duration caused by metabolic inhibition via blockade of ATP-sensitive K+ channels and Na+-activated K+ channelsJ. Pharmacol. Exp. Ther.291(2),562-568(1999)

      Sato, T., Costa, A.D.T., Saito, T., et al.Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotectionJ. Pharmacol. Exp. Ther.316(1),182-188(2006)

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