trans-Ned 19
Cat. No.:YN360131
CAS No. :1354235-96-3
产品名称: | trans-Ned 19 |
CAS No.: | 1354235-96-3 |
Chemical Name: | (1R,3S)-1-[3-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid |
Synonyms: | |
分子量: | 514.59 |
分子式: | C₃₀H₃₁FN₄O₃ |
SMILES: | O=C([C@@H]1CC2=C([C@@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | trans-Ned 19 是一种NAADP拮抗剂和TPC阻断剂,抑制人脐静脉内皮细胞 (HUVEC) 中的钙信号 (calcium signal)和响应低组胺浓度的大鼠主动脉松弛。 |
IC50和靶点: | |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Lam, A.K.M., and Galione, A.The endoplasmic reticulum and junctional membrane communication during calcium signalingBiochim. Biophys. Acta1833(11),2542-2559(2013)
Naylor, E., Arredouani, A., Vasudevan, S.R., et al.Identification of a chemical probe for NAADP by virtual screeningNat. Chem. Biol.5(4),220-226(2009)
Rosen, D., Lewis, A.M., Mizote, A., et al.Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptorJ. Biol. Chem.284(50),34930-34934(2009)
Song, E.K., Lee, Y.R., Kim, Y.R., et al.NAADP mediates insulin-stimulated glucose uptake and insulin sensitization by PPARγ in adipocytesCell Rep.2(6),1607-1619(2012)
Sakurai, Y., Kolokoltsov, A.A., Chen, C.C., et al.Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatmentScience347(6225),995-998(2015)
Thai, T.L., Churchill, G.C., and Arendshorst, W.J.NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arteriolesAm. J. Physiol. Renal. Physiol.297(2),F510-F516(2009)