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> 产品中心 > 抑制剂 & 激动剂 > Membrane Transporter/Ion Chann > Calcium Channel

trans-Ned 19

Cat. No.:YN360131

  • CAS No. :1354235-96-3

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    • 产品名称: trans-Ned 19
      CAS No.: 1354235-96-3
      Chemical Name: (1R,3S)-1-[3-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
      Synonyms:
      分子量:514.59
      分子式:C₃₀H₃₁FN₄O₃
      SMILES:O=C([C@@H]1CC2=C([C@@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: trans-Ned 19 是一种NAADP拮抗剂和TPC阻断剂,抑制人脐静脉内皮细胞 (HUVEC) 中的钙信号 (calcium signal)和响应低组胺浓度的大鼠主动脉松弛。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Lam, A.K.M., and Galione, A.The endoplasmic reticulum and junctional membrane communication during calcium signalingBiochim. Biophys. Acta1833(11),2542-2559(2013)

      Naylor, E., Arredouani, A., Vasudevan, S.R., et al.Identification of a chemical probe for NAADP by virtual screeningNat. Chem. Biol.5(4),220-226(2009)

      Rosen, D., Lewis, A.M., Mizote, A., et al.Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptorJ. Biol. Chem.284(50),34930-34934(2009)

      Song, E.K., Lee, Y.R., Kim, Y.R., et al.NAADP mediates insulin-stimulated glucose uptake and insulin sensitization by PPARγ in adipocytesCell Rep.2(6),1607-1619(2012)

      Sakurai, Y., Kolokoltsov, A.A., Chen, C.C., et al.Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatmentScience347(6225),995-998(2015)

      Thai, T.L., Churchill, G.C., and Arendshorst, W.J.NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arteriolesAm. J. Physiol. Renal. Physiol.297(2),F510-F516(2009)

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