Bay 59-3074
Cat. No.：YN320049
CAS No. ：406205-74-1
| 产品名称: | Bay 59-3074 |
| CAS No.: | 406205-74-1 |
| Chemical Name: | 4,4,4-trifluoro-1-butanesulfonic acid, 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl ester |
| Synonyms: | BAY 59-3074;[3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl] 4,4,4-trifluorobutane-1-sulfonate;Bay-59-3074;HMS3269K19;UNII-5FO5Z101GU;4,4,4-Trifluoro-1-butanesulfonic acid 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl ester |
| 分子量: | 453.36 |
| 分子式: | C₁₈H₁₃F₆NO₄S |
| SMILES: | O=S(CCCC(F)(F)F)(OC1=CC=CC(OC2=CC=CC(C(F)(F)F)=C2C#N)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bay 59-3074 是一种选择性的CB1/CB2受体的部分激动剂，其在CB1和CB2受体中的Ki值分别为 48.3 nM 和 45.5 nM。Bay 59-3074 还具有镇痛作用。 |
| IC50和靶点: | [{name:"CB1:48.3 nM (Ki)"},{name: "CB2:45.5 nM (Ki)"}] |
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| Solvent & Solubility: |
De Vry, J., and Jentzsch, K.R.Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the ratEur. J. Pharmacol.505(1-3),127-133(2004)
Teng, H., Thakur, G.A., and Makriyannis, A.Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligandsBioorg. Med. Chem. Lett.21(19),5999-6002(2011)
De Vry, J., Denzer, D., Reissmueller, E., et al.3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): A novel cannabinoid CB1/CB2 receptor partial agonist with antihyperalgesic and antiallodynic effectsJ. Pharmacol. Exp. Ther.310(2),620-632(2004)
