Ridaifen-B
Cat. No.：YN320214
CAS No. ：886465-70-9
| 产品名称: | Ridaifen-B |
| CAS No.: | 886465-70-9 |
| Chemical Name: | 1,1'-[(2-phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis-pyrrolidine |
| Synonyms: | RID-B |
| 分子量: | 510.71 |
| 分子式: | C₃₄H₄₂N₂O₂ |
| SMILES: | CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN3CCCC3)C=C2)\C4=CC=C(OCCN5CCCC5)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ridaifen-B (RID-B) 是一种有效的雌激素受体 (ERα) 拮抗剂，IC50值为 52.4 nM，是他莫西芬 (HY-13757A) 的衍生物。Ridaifen-B (RID-B) 是一种高亲和力，选择性，逆激动剂，作用于CB2受体 (Ki=43.7 nM)，是CB1受体 (Ki=300 nM) 选择性的 17 倍。Ridaifen-B 调节 G 蛋白 (IC50=300 nM) 和腺苷基环化酶活性 (IC50=134 nM)。Ridaifen-B 具有抗炎，抗肿瘤、抗破骨细胞的作用。 |
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Guo, W.-Z., Wang, Y., Umeda, E., et al.Search for novel anti-tumor agents from ridaifens using JFCR39, a panel of human cancer cell linesBiol. Pharm. Bull.36(6),1008-1016(2013)
Franks, L.N., Ford, B.M., Fujiwara, T., et al.The tamoxifen derivative ridaifen-B is a high affinity selective CB2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effectsToxicol. Appl. Pharmacol.353,31-42(2018)
Shiina, I., Sano, Y., Nakata, K., et al.Synthesis and pharmacological evaluation of the novel pseudo-symmetrical tamoxifen derivatives as anti-tumor agentsBiochem. Pharmacol.75(5),1014-1026(2008)
Nagahara, Y., Takeyoshi, M., Sakemoto, S., et al.Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvementBiochem. Biophys. Res. Commun.435(4),657-663(2013)
