Leelamine hydrochloride
Cat. No.：YN320408
| 产品名称: | Leelamine hydrochloride |
| CAS No.: | 16496-99-4 |
| Chemical Name: | 1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine, monohydrochloride |
| Synonyms: | 脱氢松香胺盐酸盐 |
| 分子量: | 321.93 |
| 分子式: | C₂₀H₃₂ClN |
| SMILES: | NC[C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C=C(C(C)C)C=C3.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Leelamine hydrochloride 是一种从松树皮中提取的三环二萜分子。Leelamine hydrochloride 是一种大麻素 1 型 (CB1) 激动剂，也是前列腺癌细胞中 SREBP1 调节的脂肪酸/脂质合成的抑制剂，不受雄激素受体状态的影响。Leelamine hydrochloride 抑制调节脂肪酸合成的雄激素受体 (androgen receptor) 的转录活性。 |
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Martin, B.R.Leelamine,(2006)
Aicher, T.D., Damon, R.E., Koletar, J., et al.Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)Bioorg. Med. Chem. Lett.9(15),2223-2228(1999)
Wilkerson, W., DeLucca, I., Galbraith, W., et al.Antiinflammatory phospholipase-A2 inhibitorsEur. J. Med. Chem.26(7),667-676(1991)
