Tetrahydromagnolol
Cat. No.：YN320502
| 产品名称: | Tetrahydromagnolol |
| CAS No.: | 20601-85-8 |
| Chemical Name: | 5,5'-dipropyl-[1,1'-biphenyl]-2,2'-diol |
| Synonyms: | Magnolignan |
| 分子量: | 270.37 |
| 分子式: | C₁₈H₂₂O₂ |
| SMILES: | OC1=CC=C(CCC)C=C1C2=CC(CCC)=CC=C2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tetrahydromagnolol (Magnolignan)，是 Magnolol 的主要代谢产物，是一种有效的选择性大麻素CB2受体激动剂，EC50为 170 nM，Ki为 416 nM。Tetrahydromagnolol 对CB2受体的选择性比 CB1 受体高 20 倍。Tetrahydromagnolol 也是一种弱的GPR55受体拮抗剂。 |
| IC50和靶点: | [{name:"CB2:170 nM (EC50)"},{name: "CB2:416 nM (Ki)"},{name: "CB1:9010 nM (EC50)"},{name: "CB1:2260 nM (Ki)'}, 'GPR55 receptor'] |
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Rempel, V., Fuchs, A., Hinz, S., et al.Magnolia extract, magnolol, and metabolites: Activation of cannabinoid CB2 receptors and blockade of the related GPR55ACS Med. Chem. Lett.4(1),41-45(2013)
Yokota, T., and Sasaki, M.Development of whitening cosmetics with magnolignan on inhibitory effect of the maturation of tyrosinaseFragr. J.34(2),80-83(2006)
