CB1 antagonist 2
Cat. No.：YN320503
CAS No. ：614726-85-1
| 产品名称: | CB1 antagonist 2 |
| CAS No.: | 614726-85-1 |
| Chemical Name: | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide |
| Synonyms: | AM4113 |
| 分子量: | 380.66 |
| 分子式: | C₁₇H₁₂Cl₃N₃O |
| SMILES: | O=C(N)C1=NN(C(C2=CC=C(C=C2)Cl)=C1C)C3=CC=C(C=C3Cl)Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CB1 antagonist 2 从专利 WO2016184310A1 中获得，caimabinoid 1 (CB1) 拮抗剂，化合物 3，在体内抑制 CB1 的IC50值为 25.5 nM。 |
| IC50和靶点: | |
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Sink, K.S., McLaughlin, P.J., Wood, J.A.T., et al.The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in ratsNeurospsychopharmacology33(4),946-955(2008)
Salamone, J.D., McLaughlin, P.J., Sink, K., et al.Cannabinoid CB1 receptor inverse agonists and neutral antagonists: Effects on food intake, food-reinforced behavior and food aversionsPhysiol. Behav.91(4),383-388(2007)
Gueye, A.B., Pryslawsky, Y., Trigo, J.M., et al.The CB1 neutral antagonist AM4113 retains the therapeutic efficacy of the inverse agonist rimonabant for nicotine dependence and weight loss with better psychiatric tolerabilityInt. J. Neuropsychopharmacol.,(2016)
