Rimonabant
Cat. No.：YN320821
CAS No. ：168273-06-1
| 产品名称: | Rimonabant |
| CAS No.: | 168273-06-1 |
| Chemical Name: | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide |
| Synonyms: | 利莫那班; SR141716 |
| 分子量: | 463.79 |
| 分子式: | C₂₂H₂₁Cl₃N₄O |
| SMILES: | ClC1=CC=C(C=C1)C2=C(C(C(NN3CCCCC3)=O)=NN2C4=CC=C(C=C4Cl)Cl)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rimonabant (SR141716) 是中心大麻素受体 1(CB1)高效的、选择性的、能透过血脑屏障的拮抗剂， Ki值为 1.8 nM。Rimonabant (SR141716) 也能够抑制分枝杆菌膜蛋白3(MMPL3)。 |
| IC50和靶点: | [{name:"CB1:1.8 nM (Ki)"}] |
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| Solvent & Solubility: |
Rinaldi-Carmona, M., Barth, F., Héaulme, M., et al.SR141716A, a potent and selective antagonist of the brain cannabinoid receptorFEBS Lett.350(2-3),240-244(1994)
Malfitano, A.M., Laezza, C., Pisanti, S., et al.Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cellsBr. J. Pharmacol.153(5),1003-1010(2009)
Lee, S.H., Seo, H.J., Lee, S.H., et al.Biarylpyrazolyl oxadiazole as potent, selective, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesityJ. med. Chem.51(22),7216-7233(2008)
Bellocchio, L., Soria-Gómez, E., Quarta, C., et al.Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockadeProc. Natl. Acad. Sci. USA110(12),4786-4791(2013)
