GW842166X
Cat. No.：YN320828
| 产品名称: | GW842166X |
| CAS No.: | 666260-75-9 |
| Chemical Name: | 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| Synonyms: | 2-(2,4-二氯苯基氨基)-4-三氟甲基嘧啶-5-羧酸[(四氢吡喃-4-基)甲基]酰胺 |
| 分子量: | 449.25 |
| 分子式: | C₁₈H₁₇Cl₂F₃N₄O₂ |
| SMILES: | ClC1=CC(Cl)=C(NC2=NC=C(C(NCC3CCOCC3)=O)C(C(F)(F)F)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW842166X是有效，选择性的cannabinoid receptor 2激活剂，IC50值为63 nM。 |
| IC50和靶点: | |
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Giblin, G.M.P., O'Shaughnessy, C.T., Naylor, A., et al.Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory painJ. Med. Chem.50(11),2597-2600(2007)
Yao, B.B., Hsieh, G.C., Frost, J.M., et al.In vitro and in vivo characterization of A-796260: A selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain modelsBr. J. Pharmacol.153(2),390-401(2008)
Ribeiro, R., Wen, J., Li, S., et al.Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonistsProstaglandins Other Lipid Mediat.100-101,(2013)
