6-Iodopravadoline
Cat. No.：YN320985
CAS No. ：164178-33-0
| 产品名称: | 6-Iodopravadoline |
| CAS No.: | 164178-33-0 |
| Chemical Name: | [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone |
| Synonyms: | AM630 |
| 分子量: | 504.36 |
| 分子式: | C₂₃H₂₅IN₂O₃ |
| SMILES: | O=C(C1=C(C)N(CCN2CCOCC2)C3=C1C=CC(I)=C3)C4=CC=C(OC)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 6-Iodopravadoline (AM630) 是一种选择性的CB2拮抗剂，Ki值为 31.2 nM，对其选择性是对 CB1受体的 165 倍。 |
| IC50和靶点: | |
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Ross, R.A., Brockie, H.C., Stevenson, L.A., et al.Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630Br. J. Pharmacol.126(3),665-672(1999)
Malan, T.P., Jr., Ibrahim, M.M., Deng, H., et al.CB2 cannabinoid receptor-mediated peripheral antinociceptionPain93(3),239-245(2001)
Bisogno, T., Ortar, G., Petrosino, S., et al.Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivoBiochim. Biophys. Acta1791(1),53-60(2009)
Wang, J., Xu, Y., Zhu, L., et al.Cannabinoid receptor 2 as a novel target for promotion of renal cell carcinoma prognosis and progressionJ. Cancer Res. Clin. Oncol.,(2017)
