LY2828360
Cat. No.：YN321071
CAS No. ：1231220-79-3
| 产品名称: | LY2828360 |
| CAS No.: | 1231220-79-3 |
| Chemical Name: | 8-(2-chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine |
| Synonyms: | LY2828360;8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine;8-(2-chloro-phenyl)-2-methyl-6-(4-methyl-piperazin-1-yl)-9-(tetrahydro-pyran-4-yl)-9h-purine;O12H7VFU6P;BCP29625;BDBM50006250;SB17392;8-(2-chlorophenyl |
| 分子量: | 426.94 |
| 分子式: | C₂₂H₂₇ClN₆O |
| SMILES: | CN1CCN(C2=C3N=C(C4=CC=CC=C4Cl)N(C5CCOCC5)C3=NC(C)=N2)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY2828360 是一个作用缓慢但很有效的 G 蛋白偏倚的大麻素受体 2(CB2)激动剂，能够抑制 cAMP 的积累并激活 ERK1/2 通路。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hollinshead, S.P., Tidwell, M.W., Palmer, J., et al.Selective cannabinoid receptor type 2 (CB2) agonists: Optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic painJ. Med. Chem.56(14),5722-5733(2013)
Lin, X., Dhopeshwarkar, A.S., Huibregtse, M., et al.Slowly signaling G protein-biased CB2 cannabinoid receptor agonist LY2828360 suppresses neuropathic pain with sustained efficacy and attenuates morphine tolerance and dependenceMol. Pharmacol.93(2),49-62(2018)
