Voacamine
Cat. No.：YN321770
| 产品名称: | Voacamine |
| CAS No.: | 3371-85-5 |
| Chemical Name: | 12-methoxy-13-[(3α)-17-methoxy-17-oxovobasan-3-yl]-ibogamine-18-carboxylic acid, methyl ester |
| Synonyms: | 老刺木胺 |
| 分子量: | 704.90 |
| 分子式: | C₄₃H₅₂N₄O₅ |
| SMILES: | O=C(C1(C(C(C2)CC)N3CC2C1)C4=C(CC3)C(C=C(OC)C([C@H](CC(/C(CN5C)=C/C)C(C(OC)=O)[C@H]5C6)C7=C6C(C=CC=C8)=C8N7)=C9)=C9N4)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Voacamine 是从Voacanga Africana中分离出来的一种吲哚生物碱。Voacamine 具有强效的大麻素CB1受体拮抗活性。Voacamine 还抑制多药耐药肿瘤细胞中的 P-糖蛋白 (P-gp) 作用。 |
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Quevauviller, A., Goutarel, R., and Janot, M.M.Pharmacology of the alkaloids of Voacanga speciesAnn. Pharm. Fr.13,423-424(1955)
Kitajima, M., Iwai, M., Kikura-Hanajiri, R., et al.Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activityBioorg. Med. Chem. Lett.21(7),1962-1964(2011)
Meschini, S., Condello, M., Calcabrini, A., et al.The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cellsAutophagy4(8),1020-1033(2008)
Ramanitrahasimbola, D., Rasoanaivo, P., Ratsimamanga-Urverg, S., et al.Biological activities of the plant-derived bisindole voacamine with reference to malariaPhytother. Res.15(1),30-33(2001)
