GRK2 Inhibitor 1
Cat. No.：YN1570025
CAS No. ：24269-96-3
| 产品名称: | GRK2 Inhibitor 1 |
| CAS No.: | 24269-96-3 |
| Chemical Name: | 5-[2-(5-nitro-2-furanyl)ethenyl]-2-furancarboxylic acid, methyl ester |
| Synonyms: | |
| 分子量: | 263.2 |
| 分子式: | C12H9NO6 |
| SMILES: | COC(C1=CC=C(/C=C/C2=CC=C([N+]([O-])=O)O2)O1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) 是一种GRK2 (β-ARK1)抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Iino, M., Furugori, T., Mori, T., et al.Rational design and evaluation of new lead compound structures for selective betaARK1 inhibitorsJ. Med. Chem.45(11),2150-2159(2002)
Taguchi, K., Matsumoto, T., Kamata, K., et al.Inhibitor of G protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunctionEndocrinology153(7),2985-2996(2012)
Nimitivai, S., McElvain, M.A., and Brodie, M.S.Reversal of dopamine D2 agonist-induced inhibition of ventral tegmental area neurons by Gq-linked neurotransmitters is dependent on protein kinase C, G protein-coupled receptor kinase, and dynaminJ. Pharmacol. Exp. Ther.344(1),253-263(2013)
