Z-DEVD-FMK
Cat. No.：YN270172
| 产品名称: | Z-DEVD-FMK |
| CAS No.: | 210344-95-9 |
| Chemical Name: | N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide, 1,2-dimethyl ester |
| Synonyms: | Caspase-3 Inhibitor |
| 分子量: | 668.66 |
| 分子式: | C₃₀H₄₁FN₄O₁₂ |
| SMILES: | O=C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)[C@H](CCC(OC)=O)NC([C@H](CC(OC)=O)NC(OCC1=CC=CC=C1)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Z-DEVD-FMK 是一种特异性的不可逆的caspase-3抑制剂，IC50为 18 μM。 |
| IC50和靶点: | [{name:"Caspase-3:18 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Granville, D.J., Carthy, C.M., Jiang, H., et al.Rapid cytochrome c release, activation of caspases 3, 6, 7, and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapyFEBS Lett.437,5-10(1998)
Brockstedt, E., Rickers, A., Kostka, S., et al.Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3J. Biol. Chem.273(43),28057-28064(1998)
Lee, J., and Bogyo, M.Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumainACS Chem. Biol.5(2),233-243(2010)
Kugawa, F., Ueno, A., and Aoki, M.Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathwayBiol. Pharm. Bull.23(8),930-935(2000)
