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Z-VAD(OMe)-FMK

Cat. No.:YN270345

  • CAS No. :187389-52-2

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    • 参考文献
    • 产品名称: Z-VAD(OMe)-FMK
      CAS No.: 187389-52-2
      Chemical Name: N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide
      Synonyms:Z-Val-Ala-Asp(OMe)-FMK
      分子量:467.49
      分子式:C₂₂H₃₀FN₃O₇
      SMILES:O=C(CF)[C@H](CC(OC)=O)NC([C@H](C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) 是一种不可逆的pan-caspase抑制剂。Z-VAD(OMe)-FMK 是泛素 C 末端水解酶 L1 (UCHL1) 抑制剂。Z-VAD(OMe)-FMK 通过靶向 UCHL1 活性位点对 UCHL1 进行不可逆地修饰。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Xiang, J., Chao, D.T., and Korsmeyer, S.J.BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteasesProc. Natl. Acad. Sci. USA93(25),14559-14563(1996)

      Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49),32608-32613(1998)

      Slee, E.A., Zhu, H., Chow, S.C., et al.Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32Biochem. J.315,21-24(1996)

      Künstle, G., Leist, M., Uhlig, S., et al.ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-αImmunol. Lett.55(1),5-10(1997)

      Meraz, I.M., Melendez, B., Gu, J., et al.Activation of the inflammasome and enhanced migration of microparticle-stimulated dendritic cells to the draining lymph nodeMol. Pharmacol.9,2049-2062(2012)

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