Z-VAD-FMK
Cat. No.：YN270346
| 产品名称: | Z-VAD-FMK |
| CAS No.: | 161401-82-7 |
| Chemical Name: | N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-L-alaninamide |
| Synonyms: | Z-VAD(OH)-FMK |
| 分子量: | 453.46 |
| 分子式: | C₂₁H₂₈FN₃O₇ |
| SMILES: | O=C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(CF)=O)=O)=O)C(C)C)OCC1=CC=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Z-VAD-FMK (Z-VAD(OH)-FMK) 是一种pan caspase抑制剂。Z-VAD-FMK 不抑制泛素 C 末端水解酶 L1 (UCHL1) 活性，即使浓度高达 440 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Cain, K., Inayat-Hussain, S.H., Couet, C., et al.A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytesBiochem. J.314(Pt 1),27-32(1996)
Jacobson, M.D., Weil, M., and Raff, M.C.Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell deathJ. Cell Biol.133(5),1041-1051(1996)
Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49),32608-32613(1998)
