Asperosaponin VI
Cat. No.：YN270453
| 产品名称: | Asperosaponin VI |
| CAS No.: | 39524-08-8 |
| Chemical Name: | (3β,4α)-3-(α-L-arabinopyranosyloxy)-23-hydroxy-olean-12-en-28-oic acid, 6-O-β-D-glucopyranosyl-β-D-glucopyranosyl ester |
| Synonyms: | 川续断皂苷 VI |
| 分子量: | 929.10 |
| 分子式: | C₄₇H₇₆O₁₈ |
| SMILES: | O[C@@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@@H]2[C@@](C)(CO)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(O[C@@H]7O[C@H](CO[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)[C@@H](O)[C@H](O)[C@H]7O)=O)[C@@]5([H])CC(C)(C)CC6)([H])[C@]4(C)CC2)OC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Asperosaponin VI 是来自续断壁的一种皂苷组分。Asperosaponin VI 通过 BMP-2/p38 和 ERK1/2 信号途径诱导成骨细胞分化。Asperosaponin VI 通过增加 Bcl-2/Bax 比值，降低活性 caspase-3 表达，以及增强 p-Akt 和 p-CREB，从而抑制缺氧诱导的心肌细胞凋亡 (apoptosis)。 |
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Niu, Y., Li, Y., Huang, H., et al.Asperosaponin VI, a saponin component from Dipsacus asper wall, induces osteoblast differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathwayPhytother. Res.25(11),1700-1706(2011)
Liu, K., Liu, Y., Xu, Y., et al.Asperosaponin VI protects against bone destructions in collagen induced arthritis by inhibiting osteoclastogenesisPhytomedicine63,153006(2019)
Gong, L.-L., Yang, S., Liu, H., et al.Anti-nociceptive and anti-inflammatory potentials of Akebia saponin DEur. J. Pharmacol.845,85-90(2019)
