Aristolactam I
Cat. No.：YN270506
| 产品名称: | Aristolactam I |
| CAS No.: | 13395-02-3 |
| Chemical Name: | 8-Methoxybenzo[f]-1,3-benzodioxolo[6,5,4-cd]indol-5(6H)-one; |
| Synonyms: | Aristololactam; Aristolactam |
| 分子量: | 293.27 |
| 分子式: | C₁₇H₁₁NO₄ |
| SMILES: | O=C1NC2=C(C3=C4C(C(OC)=CC=C4)=C2)C1=CC5=C3OCO5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aristololactam I (AL-I) 是马兜铃酸I (AA-I) 的主要代谢产物，参与导致肾损伤的过程。_x000D_ Aristololactam I (AL-I) 直接损伤肾近端小管细胞，AL-I 的细胞毒性效力高于AA-I，并且这些分子的细胞毒性作用是通过caspase-3依赖性细胞凋亡介导。 |
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Vanherweghem, J., et al.: Lancet, 341, 387 (1993), Schmeiser, H., et al.: Cancer Res., 56, 2025 (1996), Arlt, V., et al.: Mutagenesis, 17, 265 (2002), Rosenquist, T., et al.: Drug Metab. Dispos., 38, 761 (2010),
