AZD-7762
Cat. No.：YN290092
CAS No. ：860352-01-8
| 产品名称: | AZD-7762 |
| CAS No.: | 860352-01-8 |
| Chemical Name: | 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide |
| Synonyms: | AZD7762 |
| 分子量: | 362.42 |
| 分子式: | C₁₇H₁₉FN₄O₂S |
| SMILES: | O=C(N[C@@H]1CNCCC1)C2=C(C=C(S2)C3=CC=CC(F)=C3)NC(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD-7762 是一种有效的ATP竞争性的细胞周期检测点激酶 (checkpoint kinase，Chk) 抑制剂，抑制Chk1的IC50为 5 nM。 |
| IC50和靶点: | [{name:"Chk1:5 nM (IC50)"},{name: "Chk2:5 nM (IC50)"}] |
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| Solvent & Solubility: |
Zabludoff, S.D., Deng, C., Grondine, M.R., et al.AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapiesMol. Cancer Ther.7,2955-2966(2008)
Mitchell, J.B., Choudhuri, R., Fabre, K., et al.In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762Clin. Cancer Res.16(7),2076-2084(2010)
Morgan, M.A., Parsels, L.A., Zhao, L., et al.Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repairCancer Res.70(12),4972-4981(2010)
