GDC-0575
Cat. No.：YN290123
CAS No. ：1196541-47-5
| 产品名称: | GDC-0575 |
| CAS No.: | 1196541-47-5 |
| Chemical Name: | N-[4-[(3R)-3-amino-1-piperidinyl]-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl]-cyclopropanecarboxamide |
| Synonyms: | ARRY-575; RG7741 |
| 分子量: | 378.27 |
| 分子式: | C₁₆H₂₀BrN₅O |
| SMILES: | O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GDC-0575 (ARRY-575, RG7741) 是高选择性，有口服活性的小分子Chk1抑制剂，其在异种移植模型中导致肿瘤缩小和生长延迟，IC50值为1.2 nM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Di Tullio, A., Rouault-Pierre, K., Abarrategi, A., et al.The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemiaNat. Commun.8(1),1679(2017)
