SCH900776
Cat. No.：YN290349
CAS No. ：891494-63-6
| 产品名称: | SCH900776 |
| CAS No.: | 891494-63-6 |
| Chemical Name: | 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine |
| Synonyms: | MK-8776 |
| 分子量: | 376.25 |
| 分子式: | C₁₅H₁₈BrN₇ |
| SMILES: | NC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SCH900776 (MK-8776) 是一种有效，选择性，可口服的Chk1抑制剂，IC50值为 3 nM；它比对CDK2 和 Chk2 的选择性分别高 50 和 500 倍。 |
| IC50和靶点: | [{name:"Chk1:3 nM (IC50)"},{name: "Chk2:1500 nM (IC50)"},{name: "CDK2:160 nM (IC50)"}] |
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| Solvent & Solubility: |
Guzi, T.J., Paruch, K., Dwyer, M.P., et al.Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screeningMol. Cancer Ther.10(4),591-602(2011)
