CCT244747
Cat. No.：YN290426
CAS No. ：1404095-34-6
| 产品名称: | CCT244747 |
| CAS No.: | 1404095-34-6 |
| Chemical Name: | 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile |
| Synonyms: | CCT244747;3-[(2R)-1-(dimethylamino)propan-2-yl]oxy-5-[[4-methoxy-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]pyrazine-2-carbonitrile;GTPL8215;SYN1216;C20H24N8O2;BDBM50401614;compound 26 [PMID: 23082860];B5880;Q27075792;(R)-3-((1-(dimethylamino)propan-2-yl) |
| 分子量: | 408.46 |
| 分子式: | C₂₀H₂₄N₈O₂ |
| SMILES: | N#CC1=NC=C(NC2=NC=C(C3=CN(C)N=C3)C(OC)=C2)N=C1O[C@H](C)CN(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCT244747 是一种有效的，可口服的，高度选择性的CHK1抑制剂，IC50值为 7.7 nM；CCT244747 可废除 G2 检查点，IC50值为 29 nM。 |
| IC50和靶点: | [{name:"Chk1:7.7 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Walton, M.I., Eve, P.D., Hayes, A., et al.CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugsClin. Cancer Res.18(20),5650-5661(2012)
