PD 407824
Cat. No.：YN290445
CAS No. ：622864-54-4
| 产品名称: | PD 407824 |
| CAS No.: | 622864-54-4 |
| Chemical Name: | 9-hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione |
| Synonyms: | PD0407824; PD-0407824; PD 0407824; PD407824; PD-407824; PD 407824 |
| 分子量: | 328.32 |
| 分子式: | C₂₀H₁₂N₂O₃ |
| SMILES: | O=C1NC(C2=C1C3=C(C=C2C4=CC=CC=C4)NC5=C3C=C(O)C=C5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD 407824 是一个检查点激酶Chk1和WEE1抑制剂，IC50分别为 47 和 97 nM。PD 407824 是一种化学 BMP 敏化剂，可提高细胞对亚阈值量的 BMP4 的敏感性。 |
| IC50和靶点: | [{name:"Chk1:47 nM (IC50)"},{name: "WEE1:97 nM (IC50)"}] |
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| Solvent & Solubility: |
Smaill, J.B., Baker, E.N., Booth, R.J., et al.Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinasesEur. J. Med. Chem.43(6),1276-1296(2008)
Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16),4896-4911(2006)
Arora, S., Bisanz, K.M., Peralta, L.A., et al.RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cellsGynecol. Oncol.118(3),220-227(2010)
Feng, L., Cook, B., Tsai, S.-Y., et al.Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiationCell Rep.15(9),2063-2075(2016)
