T16Ainh-A01
Cat. No.：YN360040
CAS No. ：552309-42-9
| 产品名称: | T16Ainh-A01 |
| CAS No.: | 552309-42-9 |
| Chemical Name: | 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide |
| Synonyms: | T16Ainh-A01| |
| 分子量: | 416.52 |
| 分子式: | C₁₉H₂₀N₄O₃S₂ |
| SMILES: | O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)CSC3=NC(C)=C(CC)C(N3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | T16Ainh-A01 是一类氨基苯基噻唑，是有效的跨膜蛋白 16A的抑制剂，抑制TMEM16A介导的氯离子电流，IC50约为1 µM。TMEM16A (ANO1)起钙激活氯离子通道(CaCC)的作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Namkung, W., Phuan, P.W., and Verkman, A.S.TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cellsJ. Biol. Chem.286(3),2365-2374(2011)
Bradley, E., Fedigan, S., Webb, T., et al.Pharmacological characterization of TMEM16A currentsChannels8(4),308-320(2014)
Davis, A.J., Shi, J., Pritchard, H.A.T., et al.Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01Br. J. Pharmacol.168,773-784(2013)
Mazzone, A., Eisenman, S.T., Strege, P.R., et al.Inhibition of cell proliferation by a selective inhibitor of the Ca2+ activated Cl- channel, Ano1Biochem. Biophys. Res. Commun.427(2),248-253(2012)
Duvvuri, U., Shiwarski, D.J., Xiao, D., et al.TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progressionCancer Res.72(13),3270-3281(2012)
