Talniflumate
Cat. No.：YN360135
| 产品名称: | Talniflumate |
| CAS No.: | 66898-62-2 |
| Chemical Name: | 2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester |
| Synonyms: | BA 7602-06 |
| 分子量: | 414.33 |
| 分子式: | C₂₁H₁₃F₃N₂O₄ |
| SMILES: | O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2)OC3OC(C4=C3C=CC=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Talniflumate (BA 7602-06) 是尼氟酸 (HY-B0493) 的前药，通过酯酶转化为尼氟酸，从而在体内发挥其活性。Talniflumate 是具有口服活性的 Ca2+激活的 Cl-通道(CaCC)阻滞剂。Talniflumate 可用作远端肠梗阻综合征囊性纤维化小鼠模型的镇痛和抗炎药。 |
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Jang, D.-J., Park, J.-S., Ko, H.-R., et al.Simultaneous determination of niflumic acid and its prodrug, talniflumate in human plasma by high performance liquid chromatographyBiomed. Chromatogr.19(1),32-35(2005)
Walker, N.M., Simpson, J.E., Levitt, R.C., et al.Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndromeJ. Pharmacol. Exp. Ther.317(1),275-283(2006)
