DCPIB
Cat. No.：YN360136
CAS No. ：82749-70-0
| 产品名称: | DCPIB |
| CAS No.: | 82749-70-0 |
| Chemical Name: | 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-butanoic acid |
| Synonyms: | DCPIB |
| 分子量: | 427.36 |
| 分子式: | C₂₂H₂₈Cl₂O₄ |
| SMILES: | O=C(O)CCCOC1=CC2=C(C(C(C3CCCC3)(CCCC)C2)=O)C(Cl)=C1Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DCPIB 是一种选择性、可逆、有效的体积调节性阴离子通道 (VRAC) 抑制剂，能够电压依赖性激活钾离子通道 TREK1 和 TRAAK，抑制 TRESK，TASK1 和 TASK3，IC50值分别为 0.14，0.95，50.72 μM。DCPIB 同时抑制肿胀激活氯电流 (ICl,swell)，在 CPAE 细胞中，IC50值为 4.1 μM。 |
| IC50和靶点: | |
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Decher, N., Lang, H.J., Nilius, B., et al.DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential durationBr. J. Pharmacol.134(7),1467-1479(2001)
Qiu, Z., Dubin, A.E., Mathur, J., et al.SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channelCell157(2),447-458(2014)
Lahey, L.J., Mardjuki, R.E., Wen, X., et al.LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMPMol. Cell.80(4),578-591(2020)
Lv, J., Liang, Y., Zhang, S., et al.DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channelsACS Chem. Neurosci.10(6),2786-2793(2019)
Zhang, Y., Zhang, H., Feustel, P.J., et al.DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbraExp. Neurol.210(2),514-520(2008)
