Selamectin
Cat. No.：YN360177
CAS No. ：220119-17-5
| 产品名称: | Selamectin |
| CAS No.: | 220119-17-5 |
| Chemical Name: | Revolution; Revolution (antibiotic); Selamectin; Stronghold; (5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a; |
| Synonyms: | 塞拉菌素 |
| 分子量: | 769.96 |
| 分子式: | C₄₃H₆₃NO₁₁ |
| SMILES: | O[C@@]12[C@@]3([H])/C(C(C)=C[C@@]1([H])C(O[C@]4([H])C[C@]5(O[C@@](C/C=C(C)/[C@@H](O[C@@]6([H])C[C@@H]([C@@H](O)[C@H](C)O6)OC)[C@@H](C)/C=C/C=C2\CO3)([H])C4)O[C@H](C7CCCCC7)[C@@H](C)CC5)=O)=N\O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Selamectin，一种半合成的大环内酯，是一种抗寄生虫剂和驱虫剂。Selamectin 激活神经元和咽肌中的谷氨酸门控氯离子通道 (glutamate-gated chloride channels)，以预防恶丝虫，淋巴丝虫和线虫感染。Selamectin 还是一种有效的 P-糖蛋白 (P-glycoprotein) 底物和抑制剂，IC50为 120 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Eshar, D., et al.: J. Am. Veterin. Med. Association., 241, 1056 (2012)
Geis-Asteggiante, L., et al.: J. Chromatograph., 1258, 43 (2012)
