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R(+)-IAA-94

Cat. No.:YN360369

  • CAS No. :54197-31-8

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    • 产品名称: R(+)-IAA-94
      CAS No.: 54197-31-8
      Chemical Name: 2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-acetic acid
      Synonyms:R(+)-Methylindazone
      分子量:357.23
      分子式:C₁₇H₁₈Cl₂O₄
      SMILES:O=C(O)COC1=CC2=C(C([C@@](C)(C3CCCC3)C2)=O)C(Cl)=C1Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: R(+)-IAA-94 (R(+)-Methylindazone) 是一种有效的氯离子 (chloride channels) 通道阻滞剂。R(+)-IAA-94 抑制 Nef-sdAb19 相互作用,并与 Nef 结合。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Landry, D.W., Reitman, M., Cragoe, E.J., Jr., et al.Epithelial chloride channel. Development of inhibitory ligandsJ. Gen. Physiol.90,779-798(1987)

      Valenzuela, S.M., Mazzanti, M., Tonini, R., et al.The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycleJ. Physiol.529.3,541-552(2000)

      Khamici, H.A., Brown, L.J., Hossain, K.R., et al.Memebers of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activityPLoS One10(1),1-19(2015)

      Costa, J.A., Nguyen, D.A., Leal-Pinto, E., et al.Wicking: A rapid method for manually inserting ion channels into planar lipid bilayersPLoS One8(5),1-9(2013)

      Liskova, S., Petrova, M., Karen, P., et al.Contribution of Ca2+-dependent Cl- channels to norepinephrine-induced contraction of femoral artery is replaced by increasing EDCF contribution during ageingBiomed. Res. Int.289361,1-9(2014)

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