Shikonin
Cat. No.：YN360943
CAS No. ：517-89-5
| 产品名称: | Shikonin |
| CAS No.: | 517-89-5 |
| Chemical Name: | 5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione |
| Synonyms: | 紫草素; C.I. 75535; Isoarnebin 4 |
| 分子量: | 288.30 |
| 分子式: | C₁₆H₁₆O₅ |
| SMILES: | O=C1C([C@H](O)C/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Shikonin 是中草药紫草的主要成分。Shikonin 是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂，IC50为 6.5 μM。Shikonin 是一种特异的丙酮酸激酶 M2 (PKM2) 抑制剂，还可以抑制TNF-α和NF-κB途径。Shikonin 通过抑制糖酵解降低外泌体 (exosome) 的分泌。 |
| IC50和靶点: | [{name:"TMEM16A chloride channel:6.5 μM (IC50)'}, 'PKM2', 'NF-κB'] |
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Kamei, R., Kitagawa, Y., Kadokura, M., et al.Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathwayBiochem. Biophys. Res. Commun.292(3),642-651(2002)
Nigorikawa, K., Yoshikawa, K., Sasaki, T., et al.A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatasesMol. Pharmacol.70(3),1143-1149(2006)
Chen, J., Xie, J., Jiang, Z., et al.Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2Oncogene30(42),4297-4306(2011)
Han, W., Li, L., Qiu, S., et al.Shikonin circumvents cancer drug resistance by induction of a necroptotic deathMol. Cancer Ther.6(5),1641-1649(2007)
Chen, X., Yang, L., Zhang, N., et al.Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1Antimicrob. Agents Chemother.47(9),2810-2816(2003)
Kim, Y.O., Hong, S.J., and Yim, S.V.The efficacy of shikonin on cartilage protection in a mouse model of rheumatoid arthritisKorean J. Physiol. Pharmacol.14(4),199-204(2010)
