Devazepide
Cat. No.：YN320302
CAS No. ：103420-77-5
| 产品名称: | Devazepide |
| CAS No.: | 103420-77-5 |
| Chemical Name: | N-[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide |
| Synonyms: | L-364,718; MK-329 |
| 分子量: | 408.45 |
| 分子式: | C₂₅H₂₀N₄O₂ |
| SMILES: | O=C(C1=CC2=C(C=CC=C2)N1)N[C@H]3N=C(C4=CC=CC=C4)C5=CC=CC=C5N(C)C3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Devazepide (L-364,718) 是一种有效、竞争性、选择性、可口服的非肽类胆囊收缩素受体 (cholecystokinin (CCK) receptor) 拮抗剂，对大鼠胰腺、牛胆囊和豚鼠大脑 CCK 受体的IC50值分别为 81 pM，45 pM 和 245 nM。Devazepide (L-364,718) 对肠胃疾病有效。 |
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Martín-Martínez, M., Bartolomé-Nebreda, J.M., Gómez-Monterrey, I., et al.Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: Potent and selective cholecystokinin-A receptor antagonistsJ. Med. Chem.40(21),3402-3407(1997)
Lotti, V.J., Pendleton, R.G., Gould, R.J., et al.In vivo pharmacology of L-364,718, a new potent nonpeptide peripheral cholecystokinin antagonistJ. Pharmacol. Exp. Ther.241(1),103-109(1987)
Dourish, C.T., Hawley, D., and Iversen, S.D.Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364,718Eur. J. Pharmacol.147(3),469-472(1988)
Zhang, H., Bao, X., Zhang, J., et al.Devazepide suppresses cell proliferation and migration, and induces apoptosis in bladder carcinomaTransl. Androl. Urol.10(5),2113-2121(2021)
