Dexloxiglumide
Cat. No.：YN320663
CAS No. ：119817-90-2
| 产品名称: | Dexloxiglumide |
| CAS No.: | 119817-90-2 |
| Chemical Name: | (4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxo-pentanoic acid |
| Synonyms: | |
| 分子量: | 461.38 |
| 分子式: | C₂₁H₃₀Cl₂N₂O₅ |
| SMILES: | O=C(O)CC[C@@H](NC(C1=CC=C(Cl)C(Cl)=C1)=O)C(N(CCCOC)CCCCC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dexloxiglumide 是一种选择性的胆囊收缩素 A 型 (CCKA) 受体拮抗剂。Dexloxiglumide 是 Loxiglumide 的活性对映体，可抑制胆囊收缩素-八肽 (CCK-8) 诱导的平滑肌细胞收缩。 |
| IC50和靶点: | |
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Morton, M.F., Barrett, T.D., Yan, W., et al.3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a novel, potent, and selective cholecystokinin 1 receptor antagonist: In vitro and in vivo pharmacological comparison with dexloxiglumideJ. Pharmacol. Exp. Ther.323(2),562-569(2007)
Scarpignato, C., Kisfalvi, I., D'Amato, M., et al.Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: Evaluation of their receptor selectivity in vivoAliment. Pharmacol. Ther.10(3),411-419(1996)
