LY294002
Cat. No.：YN420015
CAS No. ：154447-36-6
规格
价格(RMB)
库存
| 产品名称: | LY294002 |
| CAS No.: | 154447-36-6 |
| Chemical Name: | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |
| Synonyms: | SF 1101, NSC 697286 |
| 分子量: | 307.34 |
| 分子式: | C₁₉H₁₇NO₃ |
| SMILES: | O=C1C=C(OC2=C1C=CC=C2C3=CC=CC=C3)N4CCOCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY294002 是一种广谱PI3K抑制剂，抑制PI3Kα,PI3Kδ和PI3Kβ的IC50分别为 0.5, 0.57, 0.97 μM。LY294002 也可抑制CK2的活性，IC50为 98 nM。LY294002 是一种竞争性DNA-PK抑制剂，可逆结合 DNA-PK 的激酶结构域，IC50为 1.4 μM。LY294002 是一种自噬 (autophagy) 和凋亡 (apoptosis) 激活剂。 |
| IC50和靶点: | [{name:"p110α:0.5 μM (IC50)"},{name: "p110δ:0.57 μM (IC50)"},{name: "p110β:0.97 μM (IC50)"},{name: "human CK2:98 nM (IC50)"},{name: "human CK2α2:3.869 μM (IC50)"},{name: "DNA-PK:1.4 μM (IC50)"}] |
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Vlahos, C.J., Matter, W.F., Hui, K.Y., et al.A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)J. Biol. Chem.269,5241-5248(1994)
