LTURM34
Cat. No.：YN420028
CAS No. ：1879887-96-3
规格
价格(RMB)
库存
| 产品名称: | LTURM34 |
| CAS No.: | 1879887-96-3 |
| Chemical Name: | 8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one |
| Synonyms: | LTURM 34; LTURM-34 |
| 分子量: | 414.48 |
| 分子式: | C₂₄H₁₈N₂O₃S |
| SMILES: | O=C1C2=CC=CC(C3=CC=CC4=C3SC5=C4C=CC=C5)=C2OC(N6CCOCC6)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LTURM34 是一种特异的DNA-PK抑制剂 (IC50=34 nM)。与 PI3K 相比，LTURM34 对 DNA-PK 的选择性高 170 倍。LTURM34 在多种肿瘤细胞系中显示出有效的抗增殖活性。 |
| IC50和靶点: | [{name:"DNA-PK:34 nM (IC50)"},{name: "PI3Kβ:5.8 μM (IC50)"},{name: "PI4Kδ:8.5 μM (IC50)"}] |
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| Solvent & Solubility: |
Morrison, R., Al-Rawi, J.M.A., Jennings, I.G., et al.Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazinesEur. J. Med. Chem.110,326-339(2016)
