STL127705
Cat. No.：YN420113
CAS No. ：1326852-06-5
规格
价格(RMB)
库存
| 产品名称: | STL127705 |
| CAS No.: | 1326852-06-5 |
| Chemical Name: | |
| Synonyms: | Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione |
| 分子量: | 437.42 |
| 分子式: | C₂₂H₂₀FN₅O₄ |
| SMILES: | O=C1NC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC=C2C(N1C4=CC=CC(F)=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | STL127705 (Compound L) 是一种 Ku 70/80 异二聚体蛋白 (Ku 70/80 heterodimer protein) 抑制剂，抑制 Ku70/80-DNA 相互作用，IC50值为 3.5 μM。STL127705 可抑制 Ku 依赖性 DNA-PKCS 激酶的活化，IC50值为 2.5 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Weterings, E., et al.: PCT Int. Appl. (2017), WO 2017031116 A1 20170223
