CC-115
Cat. No.：YN420247
CAS No. ：1228013-15-7
规格
价格(RMB)
库存
| 产品名称: | CC-115 |
| CAS No.: | 1228013-15-7 |
| Chemical Name: | 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-pyrazino[2,3-b]pyrazin-2(1H)-one |
| Synonyms: | CC 115 |
| 分子量: | 336.35 |
| 分子式: | C₁₆H₁₆N₈O |
| SMILES: | O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CC-115 是一种有效的双重DNA-PK和mTOR抑制剂，IC50分别为 13 nM 和 21 nM。CC-115 阻断mTORC1和mTORC2信号通路。 |
| IC50和靶点: | [{name:"DNA-PK:13 nM (IC50)"},{name: "mTOR:21 nM (IC50)'}, 'mTORC1', 'mTORC2', {'PI3Kα:852 nM (IC50)"}] |
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Mortensen, D.S., Perrin-Ninkovic, S.M., Shevlin, G., et al.Optimization of a series of triazole containing mammalian target of rapamycin (mTOR) kinase inhibitors and the discovery of CC-115J. Med. Chem.58(14),5599-5608(2015)
Tsuji, T., Sapinoso, L.M., Tran, T., et al.CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitroOncotarget8(43),74688-74702(2017)
