VAL-083
Cat. No.：YN290398
CAS No. ：23261-20-3
| 产品名称: | VAL-083 |
| CAS No.: | 23261-20-3 |
| Chemical Name: | 1,2:5,6-dianhydro-galactitol |
| Synonyms: | 去水卫矛醇; Dianhydrodulcitol; Dianhydrogalactitol |
| 分子量: | 146.14 |
| 分子式: | C₆H₁₀O₄ |
| SMILES: | O[C@H]([C@H](O)[C@]1(OC1)[H])[C@@]2([H])CO2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VAL-083 是一种烷化剂 (alkylator)，能够在 DNA 上产生 N7 甲基化，具有抗肿瘤活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Institóris, E., and Tamás, J.Alkylation by 1,2:5,6-dianhydrogalactitol of deoxyribonucleic acid and guanosineBiochem. J.185(3),659-666(1980)
Shanmuganm, K., Srinivasan, M., and Neelakantan, H.Insights into in vitro phenotypic plasticity, growth and secondary metabolites of the mycobiont isolated from the lichen Platygramme caesiopruinosaArch. Microbiol.204(1),90(2021)
Jiménez-Alcázar, M., Curiel-García, Á., Nogales, P., et al.Dianhydrogalactitol overcomes multiple temozolomide resistance mechanisms in glioblastomaMol. Cancer Ther.20(6),1029-1038(2021)
Jiang, X., Huang, Y., Wang, X., et al.Dianhydrogalactitol, a potential multitarget agent, inhibits glioblastoma migration, invasion, and angiogenesisBiomed. Pharmacother.91,1065-1074(2017)
