INDY
Cat. No.：YN440112
CAS No. ：1169755-45-6
规格
价格(RMB)
库存
| 产品名称: | INDY |
| CAS No.: | 1169755-45-6 |
| Chemical Name: | 1Z-(3-ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone |
| Synonyms: | |
| 分子量: | 235.30 |
| 分子式: | C₁₂H₁₃NO₂S |
| SMILES: | CC(/C=C1SC2=CC=C(O)C=C2N\1CC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | INDY 是一种有效，ATP 竞争性的Dyrk1A和Dyrk1B抑制剂，IC50分别为 0.24 μM 和 0.23 μM。INDY 结合在酶的 ATP 口袋中，对 Dyrk1A 的Ki值为 0.18 μM。INDY 大大降低了原代胶质母细胞瘤 (GBM) 细胞系和神经祖细胞中正常细胞和致瘤细胞的自我更新能力。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Ogawa, Y., Nonaka, Y., Goto, T., et al.Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1ANat. Commun.1:86,(2010)
Wang, P., Alvarez-Perez, J.C., Felsenfeld, D.P., et al.A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replicationNat. Med.21(4),383-388(2015)
