ML364
Cat. No.：YN290022
CAS No. ：1991986-30-1
| 产品名称: | ML364 |
| CAS No.: | 1991986-30-1 |
| Chemical Name: | 2-[[(4-methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-benzamide |
| Synonyms: | ML 364,ML-364 |
| 分子量: | 517.54 |
| 分子式: | C₂₄H₁₈F₃N₃O₃S₂ |
| SMILES: | O=C(NC1=NC(C2=CC=CC=C2)=CS1)C3=CC=C(C(F)(F)F)C=C3NS(=O)(C4=CC=C(C)C=C4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML364 是一种泛素蛋白特异性肽酶 (USP2) 抑制剂 (IC50=1.1 μM)，具有抗增殖活性，可直接结合 USP2 (Kd=5.2 μM)，诱导细胞周期蛋白 D1 降解增加并导致细胞周期停滞。ML364 增加线粒体活性氧 (ROS) 水平，降低胞内 ATP 含量。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Davis, M.I., Pragani, R., Fox, J.T., et al.Small molecule inhibition of the ubiquitin-specific protease USP2 accelerates cyclin D1 degradation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma modelsJ. Biol. Chem.291(47),24628-24640(2016)
