GNE-6640
Cat. No.：YN290138
CAS No. ：2009273-67-8
| 产品名称: | GNE-6640 |
| CAS No.: | 2009273-67-8 |
| Chemical Name: | 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]-phenol |
| Synonyms: | 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridyl]phenol;4-(2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl)phenol;4-[2-Amino-4-Ethyl-5-(1h-Indazol-5-Yl)pyridin-3-Yl]phenol;BCP31358;BDBM50250963;ZB1503;GNE 6640; GNE6640;AK00799504;A16883;NC1=NC=C(C(=C1C1=C |
| 分子量: | 330.38 |
| 分子式: | C₂₀H₁₈N₄O |
| SMILES: | OC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE-6640 是泛素特异性肽酶 7(USP7)选择性的、非共价结合的抑制剂，其对USP7 全长，USP7 催化结构域，USP43 全长以及 Ub-MDM2 的IC50值分别为 0.75 μM，0.43 μM，20.3 μM 和 0.23 μM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Kategaya, L., Di Lello, P., Rouge, L., et al.USP7 small-molecule inhibitors interfere with ubiquitin bindingNature550(7677),534-538(2017)
