IU1-47
Cat. No.：YN290178
CAS No. ：670270-31-2
| 产品名称: | IU1-47 |
| CAS No.: | 670270-31-2 |
| Chemical Name: | 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)-ethanone |
| Synonyms: | IU1-47;IU1 47;IU147 |
| 分子量: | 330.85 |
| 分子式: | C₁₉H₂₃ClN₂O |
| SMILES: | CC1=CC(C(CN2CCCCC2)=O)=C(N1C3=CC=C(C=C3)Cl)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IU1-47 是一种有效的特异性USP14抑制剂，IC50为 0.6 μM。IU1-47 抑制 IsoT/USP5， IC50为 20 μM。IU1-47 在培养的神经元中诱导 tau 蛋白降解。 |
| IC50和靶点: | |
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Boselli, M., Lee, B.-H., Robert, J., et al.An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neuronsJ. Biol. Chem.292(47),19209-19225(2017)
Han, K.H., Kwak, M., Lee, T.H., et al.USP14 inhibition regulates tumorigenesis by inducing autophagy in lung cancer in vitroInt. J. Mol. Sci.20(21),5300(2019)
