VLX1570
Cat. No.：YN290204
CAS No. ：1431280-51-1
| 产品名称: | VLX1570 |
| CAS No.: | 1431280-51-1 |
| Chemical Name: | 3,5-bis[(4-fluoro-3-nitrophenyl)methylene]hexahydro-1-(1-oxo-2-propen-1-yl)-4H-azepin-4-one |
| Synonyms: | |
| 分子量: | 469.39 |
| 分子式: | C₂₃H₁₇F₂N₃O₆ |
| SMILES: | O=C1/C(CN(C(C=C)=O)CC/C1=C\C2=CC=C(F)C([N+]([O-])=O)=C2)=C/C3=CC=C(F)C([N+]([O-])=O)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VLX1570是蛋白酶体脱泛素酶 (DUBs) 的竞争性抑制剂，IC50约10 μM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Wang, X., D'Arcy, P., Caulfield, T.R., et al.Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15Chem. Biol. Drug Des.86(5),1036-1048(2015)
Wang, X., Mazurkiewicz, M., Hillert, E.-K., et al.The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cellsSci. Rep.6:26979,(2016)
