TCID
Cat. No.:YN290437
产品名称: | TCID |
CAS No.: | 30675-13-9 |
Chemical Name: | 4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione |
Synonyms: | 4,5,6,7-Tetrachloroindan-1,3-dione |
分子量: | 283.92 |
分子式: | C₉H₂Cl₄O₂ |
SMILES: | O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | TCID (4,5,6,7-Tetrachloroindan-1,3-dione) 是一种有效的选择性神经元泛素 C 末端水解酶 (UCH-L3) 抑制剂,IC50为 0.6 μM。TCID 减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。 |
IC50和靶点: | |
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Mason, D.E., Ek, J., Peters, E.C., et al.Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometryBiochemistry43(21),6535-6544(2004)
Setsuie, R., Sakurai, M., Sakaguchi, Y., et al.Ubiquitin dimers control the hydrolase activity of UCH-L3Neurochem. Int.54(5-6),314-321(2009)
Wada, H., Kito, K., Caskey, L.S., et al.Cleavage of the C-terminus of NEDD8 by UCH-L3Biochem. Biophys. Res. Commun.251(3),668-692(1998)
Iphöfer, A., Kummer, A., Nimtz, M., et al.Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probesChembiochem13(10),1416-1420(2012)
Liu, Y., Lashuel, H.A., Choi, S., et al.Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell lineChem. Biol.10(9),837-846(2003)