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TCID

Cat. No.:YN290437

  • CAS No. :30675-13-9

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    • 参考文献
    • 产品名称: TCID
      CAS No.: 30675-13-9
      Chemical Name: 4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione
      Synonyms:4,5,6,7-Tetrachloroindan-1,3-dione
      分子量:283.92
      分子式:C₉H₂Cl₄O₂
      SMILES:O=C1CC(C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: TCID (4,5,6,7-Tetrachloroindan-1,3-dione) 是一种有效的选择性神经元泛素 C 末端水解酶 (UCH-L3) 抑制剂,IC50为 0.6 μM。TCID 减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Mason, D.E., Ek, J., Peters, E.C., et al.Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometryBiochemistry43(21),6535-6544(2004)

      Setsuie, R., Sakurai, M., Sakaguchi, Y., et al.Ubiquitin dimers control the hydrolase activity of UCH-L3Neurochem. Int.54(5-6),314-321(2009)

      Wada, H., Kito, K., Caskey, L.S., et al.Cleavage of the C-terminus of NEDD8 by UCH-L3Biochem. Biophys. Res. Commun.251(3),668-692(1998)

      Iphöfer, A., Kummer, A., Nimtz, M., et al.Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probesChembiochem13(10),1416-1420(2012)

      Liu, Y., Lashuel, H.A., Choi, S., et al.Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell lineChem. Biol.10(9),837-846(2003)

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