DUB-IN-2
Cat. No.：YN290483
CAS No. ：924296-19-5
| 产品名称: | DUB-IN-2 |
| CAS No.: | 924296-19-5 |
| Chemical Name: | 9-(ethoxyimino)-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
| Synonyms: | |
| 分子量: | 275.26 |
| 分子式: | C₁₅H₉N₅O |
| SMILES: | N#CC1=C(C#N)N=C2C(/C(C3=C2C=CC=C3)=N/OCC)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DUB-IN-2 是一种有效的deubiquitinase抑制剂，能够抑制 USP8 的活性，IC50值为 0.28 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Colombo, M., Vallese, S., Peretto, I., et al.Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymesChemMedChem5(4),552-558(2010)
Xiong, W., Gao, X., Zhang, T., et al.USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapyNat. Commun.13(1),1700(2022)
Xie, F., Zhou, X., Li, H., et al.USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRIIEMBO J.41(16),e108791(2022)
