Deguelin
Cat. No.：YN420165
CAS No. ：522-17-8
规格
价格(RMB)
库存
| 产品名称: | Deguelin |
| CAS No.: | 522-17-8 |
| Chemical Name: | 13,13aS-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-[1]benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aS)-one |
| Synonyms: | 鱼藤素; (-) |
| 分子量: | 394.42 |
| 分子式: | C₂₃H₂₂O₆ |
| SMILES: | O=C1[C@]2([H])[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC=C14 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Deguelin是一种天然存在的类胡萝卜素，是一种有效的PI3K/AKT抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Fang, N., and Casida, J.E.Anticancer action of cubé insecticide: Correlation for rotenoid constituents between inhibition of NADH: Ubiquinone oxidoreductase and induced ornithine decarboxylase activitiesProc. Natl. Acad. Sci. USA95,3380-3384(1998)
Chun, K.H., Kosmeder, J.W., II, Sun, S., et al.Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cellsJ. Natl. Cancer Inst.95(4),291-302(2003)
Lee, H.Y., Oh, S.H., Woo, J.K., et al.Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesisJ. Natl. Cancer Inst.97(22),1695-1699(2005)
Peng, X.H., Karna, P., O'Regan, R.M., et al.Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cellsMol. Pharmacol.71,101-111(2007)
Lee, H.Y., Suh, Y.A., Kosmeder, J.W., et al.Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cellsClin. Cancer Res.10,1074-1079(2004)
Caboni, P., Sherer, T.B., Zhang, N., et al.Rotenone, deguelin, their metabolites, and the rat model of Parkinson's diseaseChem. Res. Toxicol.17,1540-1548(2004)
