HPOB
Cat. No.：YN270391
CAS No. ：1429651-50-2
| 产品名称: | HPOB |
| CAS No.: | 1429651-50-2 |
| Chemical Name: | 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide |
| Synonyms: | HPOB;Benzeneacetamide, 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-;4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide |
| 分子量: | 314.34 |
| 分子式: | C₁₇H₁₈N₂O₄ |
| SMILES: | O=C(N(CCO)C1=CC=CC=C1)CC2=CC=C(C(NO)=O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HPOB 是一种高效、选择性的HDAC6抑制剂，IC50为 56 nM。HPOB 显示对其他 HDAC 的效力降低了 30 倍以上。HPOB 提高 DNA 损伤抗癌药物在转化细胞中的有效性。HPOB 不阻断 HDAC6 的泛素结合活性。 |
| IC50和靶点: | [{name:"HDAC6:0.056 μM (IC50)"},{name: "HDAC3/NCOR2:1.7 μM (IC50)"},{name: "HDAC8:2.8 μM (IC50)"},{name: "HDAC1:2.9 μM (IC50)"},{name: "HDAC10:3.0 μM (IC50)"},{name: "HDAC2:4.4 μM (IC50)"}] |
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| Solvent & Solubility: |
Fang, K., Schlingmann, G., Enos, A., et al.New biotransformation products of nemadectinsJ. Antibiot. (Tokyo)54(10),805-809(2001)
