GR 103691
Cat. No.：YN1730012
CAS No. ：162408-66-4
| 产品名称: | GR 103691 |
| CAS No.: | 162408-66-4 |
| Chemical Name: | 4′-acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1′-biphenyl]-4-carboxamide |
| Synonyms: | |
| 分子量: | 485.62 |
| 分子式: | C₃₀H₃₅N₃O₃ |
| SMILES: | O=C(C1=CC=C(C2=CC=C(C(C)=O)C=C2)C=C1)NCCCCN3CCN(C4=CC=CC=C4OC)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GR 103691 是一种有效的选择性多巴胺 D3受体拮抗剂，Ki值为 0.4 nM。GR 103691 对人多巴胺 D3的选择性超过 D4和 D1的 100 倍以上。 |
| IC50和靶点: | |
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Murray, P.J., Harrison, L.A., Johnson, M.R., et al.A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptorBioor. Med. Chem. Lett.5(3),219-222(1995)
Audinot, V., Newman-Tancredi, A., Gobert, A., et al.A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194J. Pharmacol. Exp. Ther.287(1),187-197(1998)
Diaz, M.R., Chappell, A.M., Christian, D.T., et al.Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdalaNeuropsychopharmacology36(5),1090-1103(2011)
