ABT-724 trihydrochloride
Cat. No.：YN1730018
CAS No. ：587870-77-7
| 产品名称: | ABT-724 trihydrochloride |
| CAS No.: | 587870-77-7 |
| Chemical Name: | 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole, trihydrochloride |
| Synonyms: | ABT 724;ABT724 |
| 分子量: | 402.75 |
| 分子式: | C₁₇H₂₂Cl₃N₅ |
| SMILES: | [H]Cl.[H]Cl.[H]Cl.C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ABT-724 trihydrochloride 是一种有效且高度选择性的多巴胺D4受体激动剂，对人多巴胺D4受体的EC50为 12.4 nM。ABT-724 trihydrochloride 是大鼠D4(EC50为 14.3 nM) 和雪貂D4受体 (EC50为 23.2 nM) 的有效部分激动剂，对多巴胺 D1，D2，D3或 D5受体没有影响。ABT-724 trihydrochloride 可用于研究勃起功能障碍，并具有较少的副作用。 |
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Cowart, M., Latshaw, S.P., Bhatia, P., et al.Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunctionJ. Med. Chem.47(15),3853-3864(2004)
Sanna, F., Contini, A., Melis, M.R., et al.Role of dopamine D4 receptors in copulatory behavior: Studies with selective D4 agonists and antagonists in male ratsPharmacol. Biochem. Behav.137,110-118(2015)
Yin, P., Cao, A.-H., Yu, L., et al.ABT-724 alleviated hyperactivity and spatial learning impairment in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorderNeurosci. Lett.580,142-146(2014)
