(+)-PD 128907 hydrochloride
Cat. No.：YN1730035
CAS No. ：300576-59-4
| 产品名称: | (+)-PD 128907 hydrochloride |
| CAS No.: | 300576-59-4 |
| Chemical Name: | 3,4,4aR,10bR-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol, monohydrochloride |
| Synonyms: | |
| 分子量: | 285.77 |
| 分子式: | C₁₄H₂₀ClNO₃ |
| SMILES: | CCCN1[C@@]2([H])[C@@](OCC1)([H])C3=CC(O)=CC=C3OC2.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (+)-PD 128907 hydrochloride 是多巴胺D2/D3受体的选择性激动剂，其在人类和大鼠中对D3的Ki值分别为0.7，0.84 nM，对D2的Ki值分别为179，770 nM。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Akunne, H.C., Towers, P., Ellis, G.J., et al.Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cellsLife Sci.57(15),1401-1410(1995)
Pugsley, T.A., Davis, M.D., Akunne, H.C., et al.Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907J. Pharmacol. Exp. Ther.275(3),1355-1366(1995)
Bristow, L.J., Cook, G.P., Gay, J.C., et al.The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the ratNeuropharmacology35(3),285-294(1996)
Witkin, J., Gasior, M., Acri, J., et al.Atypical antipsychotic-like effects of the dopamine D3 receptor agonist, (+)-PD 128,907Eur. J. Pharmacol.347(2-3),R1-R3(1998)
Carcinella, S., Drui, G., Boulet, S., et al.Implication of dopamine D3 receptor activation in the reversion of Parkinson's disease-related motivational deficitsTransl. Psychiatry4(6),e401(2014)
Gil-Mast, S., Kortagere, S., Kota, K., et al.An amino acid residue in the second extracellular loop determines the agonist-dependent tolerance property of the human D3 dopamine receptorACS Chem Neurosci.4(6),940-951(2013)
